我打算在 2039 年之前尝试实现不朽。 一年时间过去，而我的生物学年龄保持不变。 我邀请你与我同行。 寻找青春之泉，是人类讲述过的最古老的故事。这是梦想者们几千年来的梦想，但始终遥不可及、令人痛苦。 而在地球生命史上，第一次，就在过去 24 个月里，这扇窗口被真正打开了——一个有意识的生命体，开始现实地朝着这个目标努力。这是一个完全疯狂的时刻。 我们目前并不知道 2039 年的不朽将如何实现。已经出现了一些前景可观的新疗法，能够让生物时钟倒退几十年，但它们还不稳定——有时会意外引发癌症。我们必须解决这些问题。 但我们知道不朽是可能的，因为自然界已经解决过这个问题。这不是像“超光速飞行”那样的物理难题，而是一个生物工程问题——而进化，已经多次破解了它。 淡水水螅可以不断再生自身细胞，不会衰老，几乎没有年龄概念。“永生水母”（Turritopsis dohrnii）可以把自身细胞逆转回年轻状态，并无限次重启生命周期。龙虾会产生一种特别活跃的端粒酶，保护端粒、避免 DNA 随年龄退化。我们需要把这套“软件”移植到人类身上。 2039 年是一个合理的目标，因为 AI 驱动的创新速度正在加速。AI 正在从“助手”演变为“科学家”，为研究人员提供此前无法想象的能力，加速发现与开发。 再加上更强的生物标志物测量能力，这将形成一个闭环的改进系统，显著提升进展速度。 这正是我过去六年一直在做的事情。尽管今天的长寿技术仍然很原始，但我亲眼看到的改善，令人震惊。 六年前，我是一个被消耗殆尽、充满炎症、42 岁的中年人——被美国垃圾食品和“创业者殉道式生活方式”撞得粉碎。六年后，我的身体在很大程度上，已经运行在精英级 18 岁的水平。这包括心血管系统、生育能力、力量与激素水平。 当然，也并非一切完美。我的左耳有轻到中度听力损失，目前无法修复；我的大脑在解剖学上仍是 42 岁（而我现在 48 岁）。 即便如此，结果依然不可思议。 我和团队是通过科学方法做到这一点的。我们测量了每一个器官的生物学年龄，参考了关于延缓衰老与逆转衰老的最佳科学证据，系统性地执行这些方案，然后再次测量。反复如此。 如果我们拥有更好的测量工具和更好的疗法，我们可以做得更多、更快。而这两者，正在全球各地同时“烹饪中”。 为了进一步加速学习，我目前正在培养成千上万个 Bryan Johnson 的器官克隆体（体外培养）。这将让我可以在不冒身体风险的情况下，针对我的生物学特征测试药物与分子，加速发现。 是的，我们会犯错。希望它们不会是致命的。当然，坏运气始终存在。但我相信命运，也相信人类终将被允许实现终极目标——不朽。 不朽当然很酷，但真正的（秘密）目标，是把我们集体的注意力，聚焦到一个积极的方向上——一个让我们对未来充满希望与兴奋的目标。 我个人非常喜欢这样的状态：拥有孩子般的心智、18 岁的身体活力，以及一生累积的智慧。 这个 2039 年目标，既关乎 AI，也关乎我们人类自身。 它关乎我们如何在孕育超级智能的过程中存活下来。 这是一件非常重大的事情。我们从未经历过，出错的空间极大。 我认为，提高我们构建安全 AI、并在此过程中不自我毁灭的概率，最好的方式之一，是把我们共同的追求，从 “YOLO（活一把就算了）”转变为 “别死”。 现在，我们是一个自杀式的物种。我们做了太多原始、愚蠢的事情。我们通过饮食和生活方式不必要地杀死自己；企业通过出售致命产品牟利；我们摧毁唯一的家园；甚至把这些行为当作美德来庆祝。这真的既扭曲又荒谬。不久之后，我们会意识到现在的自己有多么幼稚。 2039 年这个目标，正在把我们指向正确的方向。 对生命说“是”，对死亡说“不”，甚至是——反抗。 如果你有兴趣与我一起尝试，我会继续免费分享我所做的一切。我也会把这一切构建进 Blueprint，帮助你用更低的成本与更少的精力，在一个价值观一致、充满动力的社区中，做和我同样的事情。 我认为，这是可以想象到的最酷目标。很难相信，在所有曾经活过的人之中，偏偏是我们，得到了站在这个时刻的机会。 我祈祷我们有勇气，去理解并珍惜存在的神圣性；我祈祷我们有足够的勇敢，在所有试图终结她的力量面前，守护她。 我们并不知道，但也许在这片银河的一隅，我们是唯一存在过的智慧生命。我祈祷我们能成为战士、照护者与存在的守护者，并配得上这份被赐予的礼物。 I’m going to try and achieve immortality by 2039. One year of time passes and I remain the same biological age. I invite you to join me. The search for the fountain of youth is the oldest story ever told. It’s been the dream of dreamers for millennia but always painfully out of reach. For the first time in the history of life on earth, in just the past 24 months, the window has opened for a conscious being to realistically strive for this goal. It is an absolutely insane moment. We currently do not know how 2039 immortality will be achieved. There are new, promising therapies that can turn back the clock decades, but they’re buggy. Sometimes they mistakenly cause cancer. We gotta fix that. But we know immortality is possible because nature has already solved it. This isn’t a physics problem like trying to travel faster than the speed of light, it’s a biological engineering problem that evolution has cracked multiple times. The freshwater hydra constantly regenerates its own cells and doesn’t succumb to senescence. It is effectively ageless. The "immortal jellyfish" (Turritopsis dohrnii) can revert its cells back to a youthful state and restart its life cycle indefinitely. Lobsters produce an especially active form of an enzyme called telomerase that preserves their telomeres and keeps their DNA from degrading as they age. We need to port the software to humans. 2039 is a reasonable target because of the accelerated, AI-driven rate of innovation. AI is morphing from assistant to scientist. It is powering current researchers with previously unimagined capabilities to enhance discovery and development. That, coupled with enhanced biomarker measurement, creates a closed-loop system of improvement that will speed things up dramatically. This is what I’ve been doing for six years. As crude as longevity technology is today, the improvements I’ve personally seen are stunning. I started as a worn-down, inflamed, aged 42 year old who’d broken himself on the rocks of American food slop and entrepreneurship martyrdom. Six years later, my body largely operates at elite 18 year old levels. That includes my cardiovascular system, fertility, strength, and hormones. Not all is well though. I have mild to moderate hearing loss in my left ear that we can’t fix and my brain is anatomically age 42 (I’m 48). Still, unreal results. My team and I did this by following the scientific method. We measured the biological age of every organ. We referenced the best scientific evidence on how to slow aging and rejuvenate. We methodically completed these protocols and measured again. Rinse and repeat. We could do so much more and faster if we had better measurement and better therapies. Both of which are cooking all over the world right now. To speed things up now, I’m currently having thousands of Bryan Johnson organ clones built in a dish. This will allow me to test drugs and other molecules against my biology to accelerate learning and save my body from potential mishaps. Yes, we’ll make mistakes. Hopefully they won’t be fatal. And of course there’s always bad luck to contend with. But I trust in fate and I believe that destiny is going to grant the human race the pleasure of achieving the ultimate: immortality. While immortality would certainly be cool, the real (secret) objective is to focus our collective attention on a positive goal. Something that helps us feel hope and excitement for the future. I personally love the idea of having a child-like mind, 18-year-old physical vibrancy, and a lifetime of wisdom. This 2039 goal is as much about AI as it is about us humans. It’s about how we survive giving birth to superintelligence. It’s kind of a big deal. We haven’t done it before. A lot can go wrong. I figure that one of the best ways to improve the probability that we build safe AI, and don’t kill each other in the meantime, is to transform our shared aspirations from yolo to don’t die. Right now, we are a suicidal species. We do all kinds of really primitive shit. We unnecessarily kill ourselves with what we eat and how we live our lives. Companies make profits from killing other people with their products. We trash the only home we have. We celebrate these things as virtue. It’s really fucked up and backward. Soon enough we’ll realize just how infantile we are right now. The 2039 goal points us in the right direction. To say yes to life and no to death. Defiance even. If you’re interested in doing this with me, I’ll continue to share everything I do for free. I’m also going to build this out in Blueprint. We’ll help you do exactly what I’m doing, at a fraction of the cost and effort, alongside an aligned and motivated community. I think this is the coolest goal imaginable. I find it hard to believe that of all the people who’ve lived, it’s us who get the opportunity to have this moment. I pray that we have the courage to appreciate the sacredness of our existence. I pray that we will be brave enough to defend her amidst the onslaught of all the forces that would try to end her. We don’t know, but we may be the only intelligent life to exist in our corner of the galaxy. I pray we will be warriors, caretakers and stewards of existence and honor the gift that has been bestowed on us.